Frequency doubling perimetry screening mode compared to the full‐threshold mode | Semantic Scholar (2024)

The diagnostic performance of the frequency doubling perimetry C20-1 screening mode was compared to that of the C20 full-threshold mode and it appeared to perform similarly in terms of sensitivity, specificity, and area under the receiver– operating characteristic (ROC) curve.

All previously published algorithms for the interpretation of frequency doubling perimetry test results were compared in full‐threshold mode in a large group of glaucoma patients and normal subjects and none of the algorithms performed substantially better than simply counting the number of defects p’< 1% in the total deviation plot.

By using the C-20-1 strategy, a p < 1% defect anywhere showed 100% specificity with the lowest test duration, and the criteria proposed for the threshold C- 20 algorithm presented a good sensitivity-specificity balance.

In the community screening, FDT performed reliably and identified abnormalities in a significant number of persons in the high-risk group passing the eye health part of the screening, however, results from the simulated screening did not support the usefulness of one strategy over another.

Longitudinal FDT-results in a clinical study showed a higher reproducibility if the first test was discarded, and Reproducibility of screening with the N-30 protocol is comparable to the C-20 procedure if an overall score is considered.

A combination of SWAP and FDT perimetry, each targeting different neuronal pathways, may improve early glaucoma detection.

The feasibility of machine learning for medical diagnostic assistance could be demonstrated in patients from 2 independent study populations and a predictive model using automated classification is able to combine the advantages of morphology and function, resulting in a higher diagnostic power for glaucoma detection.

A diagnostic setup with classification rules for combined analysis of parameters from frequency doubling technology perimetry and structural measurements with the Heidelberg Retina Tomograph is developed and successfully combined the FDT and HRT parameters for glaucoma identification.

No test or group of tests was clearly superior for glaucoma screening, and judging performance by diagnostic odds ratio, FDT, oculokinetic perimetry, and HRT II are promising tests.

SsVEP contrast thresholds to a stimulus like the central field of the FDT test detected glaucoma better than corresponding psychophysical thresholds at 18.29 Hz, when formal controls were used, as they had in a less controlled previous study at 7.14 Hz.

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All previously published algorithms for the interpretation of frequency doubling perimetry test results were compared in full‐threshold mode in a large group of glaucoma patients and normal subjects and none of the algorithms performed substantially better than simply counting the number of defects p’< 1% in the total deviation plot.

FDP is a valid screening test for glaucoma and the scoring system described by Patel et al. provided the best results.

Preliminary results indicate that the frequency-doubled contrast test provides a quick, efficient means of screening for glaucomatous visual field loss and the use of the MOBS staircase procedure and small, localized stimuli result in the best performance for screening purposes.

This paper refines the statistical comparison of the areas under two ROC curves derived from the same set of patients by taking into account the correlation between the areas that is induced by the paired nature of the data.

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