Betaderm Side Effects: Common, Severe, Long Term (2024)

Generic name: betamethasone topical

Medically reviewed by Last updated on Dec 21, 2023.

Note: This document contains side effect information about betamethasone topical. Some dosage forms listed on this page may not apply to the brand name Betaderm.

Applies to betamethasone topical: topical application cream, topical application lotion, topical application ointment, topical application spray. Other dosage forms:

  • topical application cream, topical application foam, topical application lotion, topical application ointment

Serious side effects of Betaderm

Along with its needed effects, betamethasone topical (the active ingredient contained in Betaderm) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone topical:

More common

  • Burning or stinging
  • itching at the application site

Less common

  • Blistering, burning, crusting, dryness, or flaking of the skin
  • cracking or tightening of the skin
  • dry skin
  • flushing or redness of the skin
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • unusually warm skin


  • Blistering, peeling, or loosening of the skin

Incidence not known

  • Blindness
  • blurred vision
  • change in vision
  • decreased vision
  • eye pain
  • headache
  • loss of vision
  • nausea
  • redness and scaling around the mouth
  • tearing
  • vomiting

Other side effects of Betaderm

Some side effects of betamethasone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Raised, dark red, or wart-like spots on the skin, especially when used on the face


  • Burning, itching, and pain in hairy areas, or pus at the root of the hair

Incidence not known

  • Acne or pimples
  • burning and itching of the skin with pinhead-sized red blisters
  • increased hair growth on the forehead, back, arms, and legs
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • softening of the skin

For Healthcare Professionals

Applies to betamethasone topical: topical cream, topical foam, topical gel, topical lotion, topical ointment, topical spray.


The most commonly reported side effects were pruritus, burning, itching, irritation.


Rare (less than 0.1%): Hypersensitivity


Frequency not reported: Cushing's syndrome[Ref]


Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Folliculitis, skin infections (including bacterial, fungal and viral skin infections)

Frequency not reported: Dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infections, skin atrophy, striae, miliaria[Ref]


Uncommon (0.1% to 1%): Application site pain

Frequency not reported: Burning, itching, irritation[Ref]


Rare (less than 0.1%): Eye disorder

Postmarketing reports: cataracts, glaucoma, increased intraocular pressure, central serous chorioretinopathy[Ref]


Frequency not reported: Hyperglycemia


Frequency not reported: Glucosuria


Rare (less than 0.1%): Rebound effect

More about Betaderm (betamethasone topical)

  • Check interactions
  • Compare alternatives
  • Reviews (3)
  • Dosage information
  • During pregnancy
  • Drug class: topical steroids
  • Breastfeeding

Patient resources

Other brands

Diprolene, Diprosone, Valisone, Betamethacot, ... +5 more

Professional resources

  • Betamethasone (Topical) monograph
  • Betamethasone Valerate Lotion (FDA)

Other brands

Diprolene, Diprolene AF, Sernivo

Related treatment guides

  • Atopic Dermatitis
  • Dermatitis
  • Dermatological Disorders
  • Lichen Planus
  • Lichen Sclerosus


1. Stoppoloni G, Prisco F, Santinelli R, Sicuranza G, Giordano C. Potential hazards of topical steroid therapy. Am J Dis Child. 1983;137:1130-1.

2. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C. Cushing's syndrome after topical application of corticosteroids. Am J Dis Child. 1982;136:274-5.

3. Reymann F, Kehlet H. Hypothalamic-pituitary-adrenocortical function. Association with topical application of betamethasone dipropionate. Arch Dermatol. 1979;115:362-3.

4. Cunliffe WJ, Burton JL, Holti G, Wright V. Hazards of steroid therapy in hepatic failure. Br J Dermatol. 1975;93:183-5.

5. Walsh P, Aeling JL, Huff L, Weston WL. Hypothalamus-pituitary-adrenal axis suppression by superpotent topical steroids. J Am Acad Dermatol. 1993;29:501-3.

6. Stevens DJ. Cushing's syndrome due to the abuse of betamethasone nasal drops. J Laryngol Otol. 1988;102:219-21.

7. Flynn MD, Beasley P, Tooke JE. Adrenal suppression with intranasal betamethasone drops. J Laryngol Otol. 1992;106:827-8.

8. Salde L, Lassus A. Systemic side-effects of three topical steroids in diseased skin. Curr Med Res Opin. 1983;8:475-80.

9. Product Information. Diprolene (betamethasone topical). Schering Corporation. 2001;PROD.

10. Sneddon I. Perioral dermatitis. Br J Dermatol. 1972;87:430-4.

11. Smith EB, Breneman DL, Griffith RF, Hebert AA, Hickman JG, Maloney JM, Millikan LE, Sulica VI, Dromgoole SH, Sefton J, et al. Double-blind comparison of naftifine cream and clotrimazole/betamethasone dipropionate cream in the treatment of tinea pedis. J Am Acad Dermatol. 1992;26:125-7.

12. Barkey WF. Striae and persistent tinea corporis related to prolonged use of betamethasone dipropionate 0.05% cream/clotrimazole 1% cream (Lotrisone cream). J Am Acad Dermatol. 1987;17:518-9.

13. Grice K. Tinea of the hand and forearm. Betamethasone valerate atrophy. Proc R Soc Med. 1966;59:254-5.

14. Hellgren L. Induction of generalized pustular psoriasis by topical use of betamethasone-dipropionate ointment in psoriasis. Ann Clin Res. 1976;8:317-9.

15. Macdonald A. Topical corticosteroid preparations. Hazards and side-effects. Br J Clin Pract. 1971;25:421-5.

16. Ellis CN, Katz HI, Rex IH Jr, Shavin JS, Van Scott EJ, VanderPloeg D. A controlled clinical trial of a new formulation of betamethasone dipropionate cream in once-daily treatment of psoriasis. Clin Ther. 1989;11:768-74.

17. Kitazawa Y. Increased intraocular pressure induced by corticosteroids. Am J Ophthalmol. 1976;82:492-5.

18. Butcher JM, Austin M, McGalliard J, Bourke RD. Bilateral cataracts and glaucoma induced by long term use of steroid eye drops. BMJ. 1994;309:43.

19. Eisenlohr JE. Glaucoma following the prolonged use of topical steroid medication to the eyelids. J Am Acad Dermatol. 1983;8:878-81.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer

Betaderm Side Effects: Common, Severe, Long Term (2024)


Betaderm Side Effects: Common, Severe, Long Term? ›

Tell your doctor right away if you have any serious side effects, including: stretch marks, skin thinning/discoloration, acne, extreme/unwanted hair growth, small red bumps on the skin (folliculitis). Skin infections can become worse when this medication is used.

What are the long term side effects of betamethasone? ›

Long-term side effects

Using betamethasone for a long time without stopping can mean some of the medicine gets into your blood. If this happens, there's a very small chance it can cause serious side effects, such as adrenal gland problems, high blood sugar (hyperglycaemia), or problems with your eyesight.

Can you use betaderm long term? ›

The medication should not be continued for a period longer than 4 weeks without further consultation with your doctor. Lotion: Apply a few drops of lotion or enough to thinly cover the affected area. The lotion should be gently massaged into the area until it disappears.

What happens if you use too much betamethasone? ›

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time.

Is betaderm a strong steroid? ›

This medication is used to treat a variety of skin conditions (such as eczema, dermatitis, allergies, rash). Betamethasone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a medium-strength corticosteroid.

What are the long term side effects of clotrimazole and betamethasone? ›

High doses or long-term use of betamethasone and clotrimazole topical can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

Does steroid cream have long term effects? ›

If potent or very potent topical corticosteroids are used for a long time or over a large area, there's a risk of the medicine being absorbed into the bloodstream and causing internal side effects, such as: decreased growth in children. Cushing's syndrome.

Can I use betamethasone for a long time? ›

Do not use the medicated plasters for more than 30 days. If you're using the scalp foam, or are using betamethasone on your face, ask your doctor or pharmacist how long to use it for. Children must not use the scalp application or foam for more than 5 to 7 days. Follow the instructions that come with the medicine.

Where not to put Betaderm? ›

How to use Betaderm Cream. Use this medication on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor.

Are betaderm and betamethasone the same? ›

Along with its needed effects, betamethasone topical (the active ingredient contained in Betaderm) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

What are the symptoms of coming off of betamethasone? ›

The following symptoms and signs may occur in individuals who are withdrawing from taking steroids:
  • Weakness.
  • Fatigue.
  • Decreased appetite.
  • Weight loss.
  • Nausea.
  • Vomiting.
  • Diarrhea.
  • Abdominal pain.

Why is betamethasone illegal? ›

Betamethasone is a corticosteroid, meaning it's a man-made steroid that resembles cortisol, a natural hormone produced by the adrenal gland. While legal as a therapeutic aid for horses, it is illegal when found in the blood on race day because it's considered a possible performance-enhancer.

Is betamethasone carcinogenic? ›

Thus, betamethasone was judged to be non-carcinogenic.

How long can you stay on Betaderm? ›

The medication should not be continued for a period longer than 4 weeks without further consultation with your doctor. Lotion: Apply a few drops of lotion or enough to thinly cover the affected area. The lotion should be gently massaged into the area until it disappears. The lotion is usually applied once or twice.

Is Betaderm addictive? ›

There is no evidence that BETA SCALP APPLICATION is addictive. Some of the symptoms of an allergic reaction may include: shortness of breath; wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin.

How long does betamethasone cream stay in your system? ›

Some research suggests that suppression of cortisol levels is still apparent 96 hours after topical use of corticosteroid creams, which implies that Betamethasone valerate can stay in your system for long periods of time, possibly for up to a few weeks.

How long is it safe to use betamethasone? ›

Do not use the skin cream, ointment or lotion for more than 4 weeks without talking to your doctor. If you need treatment for a long time, they may decide you need to use a milder cream or ointment.

Does betamethasone affect the heart? ›

Conclusions: Betamethasone causes profound, but transient, suppression of FHR parameters, which can mimic fetal distress. This effect is clinically recognized by visual FHR analysis. Clinicians need to be aware of this phenomenon, in order to avoid unwarranted iatrogenic delivery.

What does betamethasone do in lungs? ›

According to the results of our study, betamethasone reduces pulmonary artery resistance, which manifests as an increase in pulmonary artery AT. In addition, increased pulmonary artery AT was associated with a reduced risk of RDS in infants.

Is betamethasone good or bad for you? ›

Infection risk warning: Steroids such as betamethasone suppress your body's immune system. This makes it harder for you to fight infections. Long-term use of betamethasone and using it in higher doses may increase your chances of getting an infection. It may also hide the symptoms of any infection you may have.


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